Aphantasia cure? Boosting visual cortex function and plasticity with acetylcholine

ezra bell asked 3 weeks ago


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So as a self-diagnosed aphantasic I’ve been wondering whether we might be underestimating the potential for neurotransmitter supplementation to improve our visualization capacity. Since the VVIQ is based on a spectrum ranging from aphantasia to hyperphantasia and pubmed aphantasia studies with EEG have shown that lower resting activity and visual cortex excitability predict stronger sensory imagery, is it possible that Acytelcholine supplementation might be an effective treatment for some percentage of the effected aphantasic population?

Here are some articles to consider:

Cortical excitability controls the strength of mental imagery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200162/


Cellular effects of acetylcholine (ACh) in the primary visual cortex during the processing of visual inputs might induce perceptual learning; i.e., long-term changes in visual perception: https://www.frontiersin.org/articles/10.3389/fnsys.2014.00172/full


Curious whether anyone else has explored this train of thought.

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